组织病理学变化医学翻译

　　病理学翻译是译声翻译公司擅长领域，与多家大型医疗机构长期保持合作关系，有专业的医学翻译团队处理此类稿件，质量可以放心，以下就是译声翻译公司专业医学翻译译员整理翻译的有关组织病理学变化翻译。

　　翻译：Histopathological Changes

　　高、中、低三个剂量组动物于非连续给药后第14天和第28天后活杀，每组动物10只，雌雄各半，经30余种脏器组织的系统病理组织学观察表明：高剂量组分别见少数散在性局灶性点灶状轻度心肌纤维呈嗜酸性变(14天见于5/10只，28天见于7/10只，28天组病变范围略较14天组增大);胸腺轻度萎缩，皮质轻度变薄(14天见于1/10只，28天见于4/10只，28天组病变程度较14天组明显);脾小体少数淋巴细胞核固缩碎裂(仅见于28天组3/10只，未见于14天组);淋巴结淋巴滤泡少数淋巴细胞核固缩碎裂(14天和28天各见1/10只)，骨髓腔分叶核粒细胞轻度减少(14天组见于1/10只。28天组见于4/10只);

　　翻译：The animals in the high-, middle- and low-dose groups were killed 14 days and 28 days after the discontinuous administration, with 10 animals in each group (5 male and 5 female). Over 30 organs and tissue underwent systematic histopathologic observation, indicating that the animals in the high-dose group respectively had disseminated focal spot mild acidophilic degeneration of a few cardiac muscle fibers (observed in 5/10 rats on the 14th day, in 7/10 on the 28th day, and the range of pathological changes on the 28th day was slightly larger than that on the 14th day); Thymus had mild atrophy and cortex had mild thinning (observed in 1/10 rats on the 14th day, in 4/10 rats on the 28th day, and the degree of pathological changes on the 28th day was more remarkable than that on the 14th day); A few lymphocytes in splenic corpuscle suffered from karyopyknosis and nuclear fragmentation (observed only in 3/10 rats on the 28th day, and not observed on the 14th day); A few lymphocytes in lymphoid follicles of lymph nodes suffered from karyopyknosis and nuclear fragmentation (observed in 1/10 rats respectively on the 14th and 28th day), and segmented granulocytes in marrow cavity decreased slightly (observed in 1/10 rats on the 14th day, and observed in 4/10 rats on the 28th day);

　　肝少数点灶状坏死，伴出血(仅见于28天组1/10只，未见于14天组);肾脏远曲小管轻度扩张，上皮细胞轻度变性(14天组见于0/10只。28天组见于4/10只，其中1只少量蛋白管型);睾丸少数曲细精管生精上皮变薄，精原细胞轻度变性(14天组见于1/5只。28天组见于2/5只);卵巢成熟卵泡部分颗粒细胞变性(14天组见于1/5只。28天组见于4/5只);其他器官组织未见明显病变。中剂量组上述病变仅发生在28天组，发生率明显减少(心、胸腺、骨髓、肾、睾丸、卵巢各1只)，程度明显减轻。低剂量组所有动物的器官组织均未见明显损伤。停药后1个月，高剂量组除1只动物肾小管轻度扩张和少量蛋白管型、1只动物小叶性局灶性肺炎外，其余动物各脏器均未见明显变化，提示给药14天和28天的大部分脏器损伤均已恢复;中、低剂量组均未见明显病变。

　　翻译：There were a few spot necroses in liver, accompanied with hemorrhage (observed only in 1/10 rats on the 28th day, and not observed on the 14th day); Distal convoluted tubules of kidney expanded mildly and epithelial cells degenerated mildly (observed in 0/10 rats on the 14th day; Observed in 4/10 rats on the 28th day, of which one rat had a few protein casts); The seminiferous epithelium of a few seminiferous tubules of testis was getting thin and spermatogonia degenerated mildly (observed in 1/5 rats on the 14 day, in 2/5 rats on the 28th day); Some granular cells in the mature follicles of ovary degenerated (observed in 1/5 rats on the 24 day, in 4/5 rats on the 28th day); No marked pathological change was observed in the other organs and tissue. The above-mentioned pathological changes in the intermediate-dose group occurred only on the 28th day, with significant reduction in the incidence (pathological changes in heart, thymus, bone marrow, kidney, testis and ovary occurred respectively in one rat) and remarkable relief of the degree. No marked injury was observed in the organs and tissue of all the animals in the low-dose group. One month after the drug withdrawal, in the high-dose group, except one animal having mild dilatation of renal tubules and a few protein casts and one animal having focal lobular pneumonia, the other animals had no marked changes in each organ, indicating that the injuries to most organs had recovered on the 14th and 28th day after the administration; No marked pathological change was observed in middle- and low-dose groups.